Medical calcium silicate

Calcium silicate (CaSi03, CS) powder, ceramics or porous materials have good biological activity in vitro and the ability to induce the deposition of bone-like apatite (HAp) layer. The formation of HAp layer promotes the osteoconduction and bone conduction of the material. Bone regeneration, and promotes the formation of chemical bonds between the material and soft/hard tissue. Calcium silicate bioceramics also have good cell compatibility. Calcium silicate is a potential new bioactive bone repair material with broad application prospects. .

In the body, porous materials should generally have good biological activity and degradability. The materials gradually degrade and are replaced by new tissue, and finally tissue repair is achieved. Early vascularization can bring various cells, biological factors and nutrients to the material, which is not only conducive to the degradation of the material, but also the ingrowth and metabolism of new tissue.

Calcium silicate bioceramic coating integrates biological activity, morphological fixation, anti-infection and other complex biological functions, and has high mechanical strength. It can be used as a new generation of bone implants to improve early healing performance and long-term implantation. into the effect.

Calcium silicate is an inorganic substance with the chemical formula: CaSiO3，  Mostly needle-like crystals, white powder. Odorless, non-toxic, soluble in strong acid, insoluble in water, alcohol and alkali. After heating to 680 ～700℃ The crystallization water is released while the crystal shape remains unchanged. It is produced by mixing silicic acid, quicklime and water in a certain proportion and performing a hydrothermal reaction to generate calcium silicate microcrystalline slurry, which is filtered, washed and dried.

Calcium silicate is non-cytotoxic and has good biological activity, which can promote the growth of osteoblasts.

Calcium silicate nanowhiskers and silk fibroin can prepare composite nanofibers with good bioactivity and degradation properties, which can be used as bone tissue repair materials.